Faculty

Reproductive and Developmental Sciences Program

Jae-Wook Jeong

Obstetrics Gynecology & Reproductive Biology

Title and Affiliations 

Dr. Jae-Wook Jeong
Associate Professor

 

Contact Information

College of Human Medicine
Michigan State University
Van Andel Institute
333 Bostwick Avenue, NE
Suite 4018A
Grand Rapids, MI 49503
Email: JaeWook.Jeong@hc.msu.edu 

Education

PhD, Korea University, 2001

Research Interests

Jeong’s laboratory focuses on studying the nuclear receptors and coregulators in both mice and human uterus.  We have identified mitogen-inducible gene 6 (Mig-6) as a down stream target of progesterone receptor (PR) and steroid receptor coactivator (SRC-1) action in the uterus.  Mig-6 plays a critical role in the regulation of uterine function and the development of endometrial hyperplasia and cancer in the presence of steroid hormones.

Recent Publications

  1. Nili Jin, Jennifer L. Gilbert, Russell R. Broaddus, Francesco J. DeMayo, and Jae-Wook Jeong (2007) Generation of a Mig-6 Conditional Null Allele. Genesis 45: 716-721 PMID: 17987665
  2. Jae-Wook Jeong, Kevin Y. Lee, Sang Jun Han, Bruce J. Aronow, John P. Lydon, Bert W. O’Malley, and Francesco J. DeMayo (2007) The p160 Steroid Receptor Coactivator 2, SRC-2 regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression. Endocrinology 148: 4238-4250 PMID: 17556502 (Cover featuring article)
  3. Kevin Y. Lee, Jae-Wook Jeong, Sophia Y. Tsai, John P. Lydon, and Francesco J. DeMayo (2007) Mouse models of implantation. Trends Endocrinol Metab. 18:234-239 PMID: 17588769
  4. Isao Kurihara, Don-Kee Lee, Fabrice Petit, Jae-Wook Jeong, Kevin Lee, John P. Lydon, Francesco J. DeMayo, Ming-Jer Tsai, and Sophia Y. Tsai. (2007) COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity. PLoS Genetics 3:1053-1064 PMID: 17590085
  5. Kevin Y. Lee, Jae-Wook Jeong, Jinrong Wang, Lijiang Ma, James F. Martin, Sophia Y. Tsai, John P. Lydon, and Francesco J. DeMayo (2007) Bmp2 is critical for the murine uterine decidual response. Mol. Cell Biol. 27:5468-78 PMID: 17515606
  6. HuaiGuang Li, Sung Nam Cho, Christopher M. Evans, Burton F. Dickey, Jae-Wook Jeong, and Francesco J. DeMayo (2008) Cre-mediated recombination in mouse Clara cells. Genesis 46:300-7. PMID: 18543320
  7. Heather L. Franco, Jae-Wook Jeong, Sophia Y. Tsai, John P. Lydon, and Francesco J. DeMayo (2008) In vivo analysis of progesterone receptor action in the uterus during embryo implantation. Semin. Cell Dev. Biol. 19: 178-186. PMID: 18280760
  8. Eiichi Hondo, Jae-Wook Jeong, Jr-Gang Cheng, Jianbo Hu, Clara I. Rodriguez, Francesco J. DeMayo, and Colin L. Stewart (2008) Regulation of embryo implantation: an informatics-based analysis of gene expression in the luminal epithelium in response to LIF and E2 In: Maruo T, Mardon H, Stewart CL eds. Translational Research in Uterine Biology: Proceedings of an International Symposium held in Kobe, Japan, 28-30 November 2007. Tokyo: Elsevier; 87-99.
  9. Heather L. Franco, Jae-Wook Jeong, Sophia Y. Tsai, John P. Lydon, and Francesco J. DeMayo (2008) Molecular Mechanisms Regulating Endometrial Function and Dysfunction. In: Maruo T, Mardon H, Stewart CL eds. Translational Research in Uterine Biology: Proceedings of an International Symposium held in Kobe, Japan, 28-30 November 2007. Tokyo: Elsevier; 101-109.
  10. Nili Jin, Sung-Nam Cho, M. Gabriela Raso, Ignacio Wistuba, Yvonne Smith, Yanan Yang, Jonathan M. Kurie, Rudolph Yen, Christopher M. Evans, Thomas Ludwig, Jae-Wook Jeong, and Francesco J. DeMayo (2009) Mig-6 is required for appropriate lung development which ensure normal adult lung homeostasis. Development 136:3347-56 PMID: 19710174
  11. Jae-Wook Jeong, Hee Sun Lee, Kevin Y. Lee, Lisa D. White, Paula Amato, Sandra Carson, Amy E. Hamilton, Linda C. Giudice, Russell R. Broaddus, Yu-Wen Zhang, George F. Vande Woude, Steven L. Young, Bruce A. Lessey, Sophia Y. Tsai, John P. Lydon, and Francesco J. DeMayo (2009) Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 106(21):8677-82 PMID: 19439667 PMCID: 2681319 (Corresponding author)
  12. Sanjeet G. Patel, Guisheng Zhou, Shi-He Liu, Min Li, Jae-Wook Jeong, Francesco J. DeMayo, Marie-Claude Gingras, Richard A. Gibbs, William E. Fisher and F. Charles Brunicardi (2009) Microarray Analysis of Somatostatin Receptor 5-Regulated Gene Expression Profiles in Murine Pancreas. World J Surg. 33(4):630-637 PMID: 19137362
  13. Jae-Wook Jeong, Hee Sun Lee, Heather L. Franco, Russell R. Broaddus, Makoto M. Taketo, Sophia Y. Tsai, John P. Lydon, and Francesco J. DeMayo (2009) b-catenin mediates glandular formation and dysregulation of b-catenin induces hyperplasia formation in the murine uterus. Oncogene. 28:31-40 PMID: 18806829 PMCID: 2646831
  14. Lidia Hernandez, Kyle J. Roux, Esther Sook Min Wong, Leslie C. Mounkes, Rafidah Mutalif, Raju Navasankari, Bina Rai, Simon Cool, Jae-Wook Jeong, Honghe Wang, Hyun-Shik Lee, Serguei Kozlov, Martin Grunert, Thomas Keeble, C. Michael Jones, Margarita D. Meta, Stephen G. Young, Ira O. Daar, Brian Burke, Alan O. Perantoni, and Colin L. Stewart (2010) Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in Progeria. Developmental Cell 19(3):413-25 PMID: 20833363
  15. Jae-Wook Jeong, Inseok Kwak, Kevin Y Lee, Tae Hoon Kim, Michael J. Large, Colin L. Stewart, Klaus H. Kaestner, John P. Lydon, and Francesco DeMayo (2010) Foxa2 is essential for murine endometrial gland development and fertility. Biol. Reprod. 83(3):396-403 PMID: 20484741
  16. Tae Hoon Kim, Heather L. Franco, Sung Yun Jung, Jun Qin, Russell R. Broaddus, John P. Lydon, and Jae-Wook Jeong (2010) The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. Oncogene 29(26):3770-3780 PMID: 20418913
  17. Dong-Kee Lee, Isao Kurihara, Jae-Wook Jeong, John Lydon, Francesco J. DeMayo, Ming-Jer Tsai, and Sophia Y. Tsai (2010) ICI 182,780, a pure ERa antagonist, partially rescued the implantation and decidualization defects in uterine specific COUP-TFII deficient mice. Mol. Endocrinol. 24(2):335-45 PMID: 20219888
  18. Heather L. Franco, Kevin Y. Lee, Cory A. Rubel, Chad J. Creighton, Lisa D. White, Russell R. Broaddus, Michael T. Lewis, Andrew P. McMahon, John P. Lydon, Jae-Wook Jeong, and Francesco J. DeMayo (2010) Constitutive activation of Smoothened in the female reproductive tissues leads to infertility and altered uterine differentiation. Biol. Reprod. 82(5):991-999 PMID: 20130264.
  19. Heather L. Franco, Kevin Y. Lee, Russell R. Broaddus, Lisa D. White, Beate Lanske, John P. Lydon, Jae-Wook Jeong, and Francesco J. DeMayo (2010) Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling. Biol. Reprod. 2010 82(4):783-90 PMID: 20056671
  20. Tae Hoon Kim, Dong-Kee Lee, Heather L. Franco, John P. Lydon, and Jae-Wook Jeong (2010) ERBB receptor feedback inhibitor 1 regulation of estrogen receptor activity is critical for uterine implantation. Biol. Reprod. 82(4):706-13 PMID: 20018910
  21. Rodrigo Fernandez-Valdivia, Jae-Wook Jeong, Atish Mukherjee, Selma M. Soyal, Jie Li, Yan Ying, Francesco J. DeMayo, and John P. Lydon (2010) A Mouse Model to Dissect the Pleiotropic Functions of Progesterone Signaling in the Female Reproductive Tract and Mammary Gland. Genesis. 48(2):106-13. PMID: 20029965
  22. Cory A. Rubel, Jae-Wook Jeong, Sophia Y. Tsai, John P. Lydon, and Francesco J. DeMayo (2010) Epithelial-stromal interaction and progesterone receptors in the mouse uterus. Semin Reprod Med. 28(1):27-35 PMID: 20104426
  23. Tae Hoon Kim, Jinrong Wang, Kevin Y. Lee, Heather L. Franco, Russell R. Broaddus, John P. Lydon, Jae-Wook Jeong, and Francesco J. DeMayo (2010) The synergistic effect of conditional Pten loss and oncogenic K-ras mutation on endometrial cancer development occurs via decreased progesterone receptor action. J. Oncology 2010:139087 PMID: 19884980 PMCID: 2768008
  24. Han-Cheon Kim, Kyung-Chul Choi, Hyo-Kyoung Choi, Hee-Bum Kang, Mi-Jeong Kim, Yoo-Hyun Lee, Ok-Hee Lee, Jeongmin Lee, Young Jun Kim, Woojin Jun, Jae-Wook Jeong, and Ho-Geun Yoon (2010) HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells. Cellular and Molecular Life Sciences 67(20):3499-510 PMID: 20473547
  25. Jin Won Choi, Sujung Kim, Tae Min Kim, Young Min Kim, Hee Won Seo, Tae Sub Park, Jae-Wook Jeong, Gwonhwa Song, and Jae Yong Han (2010) Basic Fibroblast Growth Factor Activates MEK/ERK Cell Signaling Pathway and Stimulates the Proliferation of Chicken Primordial Germ Cells. PLoS ONE 5(9):e12968 PMID: 20886037 PMCID: PMC2944891
  26. Heather L. Franco, Daisy Dai, Kevin Y. Lee, Cory A. Rubel, Dennis Roop, Derek Boerboom, Jae-Wook Jeong, John P. Lydon, Indrani C. Bagchi, Milan K. Bagchi, and Francesco J. DeMayo (2011) WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. FASEB J. 25(4):1176-87 PMID: 21163860
  27. Atul Chopra, Ramakrishna Kommagani, Pradip Saha, Jean-Francois Louet, Stina Salazar, Junghun Song, Jae-Wook Jeong, Milton J. Finegold, Benoit Viollet, Francesco J. Demayo, Lawrence C. B. Chan, David Moore, and Bert W. Omalley (2011) Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metabolism 13(1):35-43. PMID: 21195347
  28. Bin He, Tae Hoon Kim, Ramakrishna Kommagani, Qin Feng, Rainer Lanz, Jae-Wook Jeong, Francesco J. DeMayo, John P. Lydon, and Bert W. O’Malley (2011) Estrogen-Regulated Prohibitin is Required for Mouse Uterine Development and Adult Function. Endocrinology 152(3):1047-56 PMID: 21209023
  29. Ricardo F. Savaris, Jeremy M. Groll, Steven L Young, Franco J. DeMayo, Jae-Wook Jeong, Amy E. Hamilton, Linda C Giudice, and Bruce A. Lessey (2011) Progesterone Resistance in PCOS Endometrium: a Microarray Analysis in Clomiphene Citrate-Treated and Artificial Menstrual Cycles. The Journal of Clinical Endocrinology & Metabolism 96(6):1737-46 PMID:21411543
  30. Kathrin A. Dunlap, Justyna Filant, Kanako Hayashi, Edmund B. Rucker, III, Gwonhwa Song, Jian Min Deng, Richard R. Behringer, Franco J. DeMayo, John Lydon, Jae-Wook Jeong, and Thomas E. Spencer (2011) Postnatal Deletion of Wnt7a Inhibits Uterine Gland Morphogenesis and Compromises Adult Fertility in Mice. Biol Reprod. 2011 Apr 20. [Epub ahead of print] PMID: 21508348
  31. Gwonhwa Song, Hee Won Seo, Jin Won Choi, Deivendran Rengaraj, Tae Min Kim, Bo Ram Lee, Young Min Kim, Tae Won Yun, Jae-Wook Jeong and Jae Yong Han (2011) Discovery of Candidate Genes and Pathways Regulating Oviduct Development in Chickens Biol. Reprod. 2011 85(2):306-14 PMID:21543768
  32. Hyun Joon Kim, Mary C Gieske, Kourtney L Trudgen, Susan Hudgins-Spivey, Beob Gyun Kim, Andree Krust, Pierre Chambon, Jae-Wook Jeong, Eric Blalock and CheMyong Ko (2011) Identification of estradiol/ERa-regulated genes in the mouse pituitary. J. Endocrinol. 210(3):309-321 PMID:21700660