Reproductive and Developmental Sciences Program

Puliyur S. MohanKumar

College of Veterinary Medicine

  Title and Affiliations

   Puliyur.S. MohanKumar BVSc, PhD
   Position: Professor - Research Director (BIRCWH)



Contact Information

Department of Pathobiology and Diagnostic Investigation
College of Veterinary Medicine
Michigan State University
Office: B336 Life Science Building
phone: 517-353-2251
Fax: 517-353-8915
email: mohankumar@cvm.msu.edu


Research Interests

Our research mainly focuses on age-related changes in the activity of brain monoamines in discrete nuclei of the hypothalamus, specifically the arcuate nucleus and the medial preoptic area which are involved in the regulation of Luteinizing hormone (LH). We and others have provided evidence that changes in brain monoamines that occurs during aging is responsible for the altered secretory pattern of LH during middle age and for the loss of cyclicity in old age. Currently, we are focussing on the roles of ovarian steroids and GABA in mediating some of the age-related changes in hypothalamic monoamines. Another area of interest is the age-related loss of tuberoinfundibular dopaminergic (TIDA) neuron function. We are currently examining the role of estrogen in promoting loss of TIDA neuronal function through a variety of interesting mechanisms. We use Sprague-Dawley rats in our studies. We use state-of-the-art techniques such as push-pull perfusion, HPLC-EC, Palkovits´┐Ż microdissection of the brain, PCR, SDS-PAGE with western blotting, RIAs etc.


Education/Degree Information:

BVSc Madras Veterinary College 1988
PhD Kansas State University 1993
Postdoc University of Kansas Medical Center 1997